College football picks, schedule: Predictions against the spread, odds for key top 25 games in Week 2

 While the Power Five is kicking off the 2020 college football season a couple weeks later than initially scheduled as the COVID-19 pandemic has shuffled the sport's entIre schedule, the ACC and Big 12 are officially beginn

ing en masse on Saturday with nearly every team in action. The SEC is still a couple weeks away from beginning its season (Sept. 26), and the Big Ten and Pac-12 are currently surveying playing in spring 2021, but major college football is nevertheless on the deck this weekend.

Preseason No.1 Clemson makes its debut in primetime when it battles conference foe Wake Forest at home. No. 10 Notre Dame, a one-season member of the ACC, takes on Duke at home in one of the featured late afternoon matchups. No Big 12 teams are facing each other, but its most prominent members, No. 5 Oklahoma and No. 14 Texas, will be in action on Saturday night against Missouri State and UTEP, respectively. 

Let's take a look at the biggest games on the schedule Saturday along with our picks and predictions for what will transpire in those contests. Our CBS Sports college football experts have picked every game both straight up and against the spread, giving you ample opportunity to decide how to make your picks ahead of kickoff. All times Eastern

Duke at No. 10 Notre Dame (-20.5) -- 2:30 p.m. on NBC: Picking games will be harder than ever before this year because we might not find out players are missing until just before kickoff. Still, given what we know about both of these teams heading into Saturday, I have a hard time not taking the Fighting Irish. The Irish beat Duke 38-7 last season in Durham, North Carolina, and I don't think enough has changed for either team to expect this year's contest to go much differently. I feel comfortable taking the Irish at anything better than three touchdowns. Pick: Notre Dame (-20.5) -- Tom Fornelli